Abstract of research

EVALUATION OF THE EFFICACY OF DIFFERENT FORMULAE OF CONCENTRATED INACTIVATED RABIES VACCINE

Amany A. Abassa, El-Bagory, G.F.b and Khodeir, M.H.a

Abstract

There is increased cases of rabies worldwide and be afraid in everywhere. Such vaccine aimed to induce high level of more prolonged immunity in a safe manner. So the present work evaluate all prepared vaccine formulae which from different adjuvant and different doses and also by concentrated virus by PEG6000, were found free from foreign contaminants and safe induce no abnormal general or local clinical sings .The induced rabies antibodies were followed up in the sera of each puppies up to one year using serum neutralization test (SNT), indirect enzyme linked immune sorbent assay (ELISA). Both of SNT and ELISA indicated that the highest antibody level was induced by the vaccine adjuvant montanide ISA206 and inactivated by beta propiolactone and concentrated by poly ethylene glycol 6000.